The Municipality of Manciano has a temperate climate, with slightly colder winters than the coastal areas and warm but not muggy summers.
The municipality of Manciano rises in a hilly position, due to this peculiarity winters record lower average temperatures, higher levels of rainfall and moderately hot summers.
The coldest month is January, with a calculated average temperature of 4.7°C.
The warmest month is July, with an average temperature of 22 °C.
Precipitation is concentrated in autumn and winter, while summer is almost never rainy.